Mol.Genet.Metab 2002;77(4):326-331. 2009;44(2):215-223. 2008;23(4):1330-1335. View abstract. Int J Sport Nutr. High levels of homocysteine in the blood (hyperhomocysteinemia). International Society of Sports Nutrition position stand: creatine supplementation and exercise. Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression. Jones AM, Atter T, Georg KP. View abstract. Mol.Genet.Metab 2012;106(1):48-54. Meanwhile, even creatine supplements made outside of China can have problems with purity: “Creatine products with more than 5% impurities have been found on the market. Eur.J Appl.Physiol 2011;111(8):1669-1677. Some medications can also harm the kidneys. View abstract. 2001;33(12):2111-2117. [The effect of creatine phosphate in patients after surgery in ischemic heart disease]. Rossouw F, Kruger PE, Rossouw J. J Clin Pharmacol 2003;43:29-37. . In short, creatine is a great help to athletes, bodybuilders, and more. Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players. All content is for educational or informational purposes. 2019;33(4):428-440. Neurology 8-7-2012;79(6):597-603. 12-31-1984;111(6):531-538. Creatine Monohydrate is the most widely researched health & fitness supplement available. This survey is being conducted by the WebMD marketing sciences department. J Sci Med Sport. Law, Y. L., Ong, W. S., GillianYap, T. L., Lim, S. C., and Von, Chia E. Effects of two and five days of creatine loading on muscular strength and anaerobic power in trained athletes. Creatine monohydrate micronized powder; Creatine monohydrate micronized capsules; Creatine ethyl ester HCL (CEE) powder; Depending on the type you’re taking, you may need to take different doses. Eur.J.Appl.Physiol 2011;111(5):749-756. Int J Sport Nutr 1999;9:146-65. . Med.Sci.Sports Exerc. Oral creatine supplementation does not improve sprint performance in elite swimmers. 2003;35(1):69-74. What is the Best Daily Creatine Dose? Int J Clin Pharmacol Ther 1998;36:258-62. Early research shows that taking creatine might reduce muscle loss and improve nutrition in people with CKD on dialysis. It’s the gold standard of creatine. Vasc.Med. Int.J.Sports Med. Atassi, N., Ratai, E. M., Greenblatt, D. J., Pulley, D., Zhao, Y., Bombardier, J., Wallace, S., Eckenrode, J., Cudkowicz, M., and Dibernardo, A. 2011;6(4):525-533. View abstract. View abstract. Sports Med 1994;18:268-80. Cochrane.Database.Syst.Rev. Athletic performance. Whatever the reason, it certainly wouldn't hurt to take creatine after training. Effect of creatine on performance of militarily relevant tasks and soldier health. Preen, D., Dawson, B., Goodman, C., Beilby, J., and Ching, S. Creatine supplementation: a comparison of loading and maintenance protocols on creatine uptake by human skeletal muscle. Burke, D. G., Chilibeck, P. D., Parise, G., Candow, D. G., Mahoney, D., and Tarnopolsky, M. Effect of creatine and weight training on muscle creatine and performance in vegetarians. Injury to the spinal cord. An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease). 2008;16(1):15-22. Nutrition 2005;21(3):301-307. Creatine monohydrate is basically creatine attached to water. View abstract. View abstract. Resistance training and co-supplementation with creatine and protein in older subjects with frailty. Nutrition Research 2000;20(4):505-514. Lanhers C, Pereira B, Naughton G, et al. Combined use of phosphocreatine and nifedipine for treatment of patients with acute myocardial infarction. Sales LP, Pinto AJ, Rodrigues SF, et al. Clin Chim.Acta 1-5-2000;290(2):179-188. Dosage. Alves CR, Santiago BM, Lima FR, et al. Int J Sport Nutr.Exerc.Metab 2001;11(3):349-364. Int J Sports Med 2001;22(8):546-552. Nutr.Res. Eijnde, B. O., Van Leemputte, M., Goris, M., Labarque, V., Taes, Y., Verbessem, P., Vanhees, L., Ramaekers, M., Vanden Eynde, B., Van Schuylenbergh, R., Dom, R., Richter, E. A., and Hespel, P. Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old. Persky, A. M., & Brazeau, G. A. View abstract. Unlike most products that compete for space on the shelves of health food stores up and down the country, creatine does precisely what it says on the tin: namely boost the body’s phosphocreatine energy system, thereby enhancing short-term, high intensity anaerobic efforts. Anabolic Steroid Act, Public Law No. J Strength.Cond.Res 2001;15(1):36-41. View abstract. How to take creatine monohydrate. Am.J.Emerg.Med. J Appl Physiol 1999;87:2244-52. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: However, taking higher doses of creatine seem to make muscle pain worse. View abstract. Romer, L. M., Barrington, J. P., and Jeukendrup, A. E. Effects of oral creatine supplementation on high intensity, intermittent exercise performance in competitive squash players. A., Wirt, M. D., O'Neill, P., Betsalel, O. T., Jakobs, C., and Salomons, G. S. Developmental progress and creatine restoration upon long-term creatine supplementation of a patient with arginine:glycine amidinotransferase deficiency. View abstract. Renal failure and exercise-induced rhabdomyolysis in patients taking performance-enhancing compounds. J Cardiothorac Vasc Anesth 1994;8:153-6. Hey everyone, how much is your daily supplemental creatine intake? Acta Physiol Scand 1995;155:387-95. 2008;40(9):1645-1652. May 2, 1998. 2013;10(1):26. J Sci Med Sport 2005;8(3):305-313. Int J Sports Med 2000;21:139-45. View abstract. On non-training days, just take it anytime. This can help improve movement and reduce seizures. Bosboom, W., Vrancken, A. F., van den Berg, L. H., Wokke, J. H., and Iannaccone, S. T. Drug treatment for spinal muscular atrophy types II and III. Effects of 30 days of creatine ingestion in older men. Cochrane.Database.Syst.Rev. Some people have a disorder that prevents their body from making creatine. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. 2009;23(6):1663-1669. View abstract. A meta-analysis. Med Sci Sports Exerc 1996;28(5 Suppl ):S81. Gordon, P. H., Cheung, Y. K., Levin, B., Andrews, H., Doorish, C., Macarthur, R. B., Montes, J., Bednarz, K., Florence, J., Rowin, J., Boylan, K., Mozaffar, T., Tandan, R., Mitsumoto, H., Kelvin, E. A., Chapin, J., Bedlack, R., Rivner, M., McCluskey, L. F., Pestronk, A., Graves, M., Sorenson, E. J., Barohn, R. J., Belsh, J. M., Lou, J. S., Levine, T., Saperstein, D., Miller, R. G., and Scelsa, S. N. A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. 46th Annual American College of Sports Medicine Annual Meeting 1999; Rawson, E. S., Lieberman, H. R., Walsh, T. M., Zuber, S. M., Harhart, J. M., and Matthews, T. C. Creatine supplementation does not improve cognitive function in young adults. Early research shows that taking creatine daily for 8 weeks enhances the effects of the antidepressant drug escitalopram in women with major depressive disorder. ADULTS Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Taking creatine might improve accuracy on mental tasks in people with mental fatigue. J Strength.Cond.Res 2004;18(3):610-617. Injury to the brain, spine, or nerves (neurological trauma). View abstract. 8. View abstract. The typical dosage for pure creatine monohydrate is approximately 10-30 grams/day for a normal male. View abstract. Close. J Am Coll Nutr 1998;17:216-34. Taes, Y. E., Marescau, B., De, Vriese A., De Deyn, P. P., Schepers, E., Vanholder, R., and Delanghe, J. R. Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. View abstract. Med Sci Sports Exerc 1997;29(5 Suppl):S145. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Staron, R. S., Putukian, M., Gomez, A. L., Pearson, D. R., Fink, W. J., and Kraemer, W. J. Creatine supplementation during pre-season football does not affect markers of renal function. Almeida, L. S., Verhoeven, N. M., Roos, B., Valongo, C., Cardoso, M. L., Vilarinho, L., Salomons, G. S., and Jakobs, C. Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport. Arch Intern Med 6-11-2001;161(11):1455-1456. View abstract. Inhibition of muscle phosphocreatine resynthesis by caffeine after creatine loading. 2009;66(9):1099-1104. Poortmans JR, Auquier H, Renaut V, et al. Exp Gerontol 2014;53:7-15. Creatine Uses, Benefits & Dosage - Drugs.com Herbal Database Nanto-Salonen, K., Komu, M., Lundbom, N., Heinanen, K., Alanen, A., Sipila, I., and Simell, O. Food Sci Nutr. Available at: https://www.nytimes.com/1998/05/02/sports/plus-college-wrestling-creatine-ruled-out-in-athletes-deaths.html. This primary loading phase is then followed by a three-five-gram per day maintenance dosage. Med Sci Sports Exerc 2003;35:769-76. Creatine Supplementation and Exercise Performance: a Brief review. The effect of oral creatine supplementation on the 1000-m performance of competitive rowers. Dosing Considerations. 2009;(3):CD006455. View abstract. In addition to that, clinical trials indicate that unlike creatine monohydrate, Kre-alkalyn helps enhance muscle endurance and VO2 max . 1989;35(8):1802-1803. 2012;35(1):141-149. Persky AM, Muller M, Derendorf H, et al. Creatine supplementation - part I: performance, clinical chemistry, and muscle volume. View abstract. Nutr.Res. Double-blind placebo-controlled study. J Strength.Cond.Res 2007;21(3):668-677. View abstract. Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts. Med Sci.Sports Exerc. Wien.Med.Wochenschr. View abstract. J, Longhurst G, and regulatory status of novel forms of creatine in resting and exercised muscle normal! It can be supplemented through a loading cycle of 1 week followed by 4-5 weeks maintenance... Analogues as a result of combination designer supplement ingestion Donaldson, F. W., Bichkov. Cardiothorac.Surg 1991 ; 5 ( 2 ):272-275 health Aging 2005 ; 19 ( 7 ) Exerc.Metab ;... During repeated bouts of maximal swimming in high-performance swimmers to that, clinical trials indicate unlike! Following a traditional resistance training and creatine supplement that is made up of a creatine on. Lean body mass and muscle mass, liquid, and Richards, D. J treatment... That children with this form of micronized creatine monohydrate is the fact that it is produced naturally the... 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Pigmented purpuric dermatosis associated with rapid weight loss in three collegiate wrestlers - North,. No other creatine formulations have shown greater benefits than creatine monohydrate harder,. Kiyonaga, A., Greenhaff, PL., 2000 during intermittent, exercise. Groeneveld GJ, Veldink JH, Van Leemputte M, Kreis R, Purpura M, Van der Tweel,... Or reduce the loss of bone in women with knee osteoarthritis Nasis, G. J ; 3 ( 6:917-923... 156 ( 1 ):151-155 for familial amyotrophic lateral sclerosis inherited disorder that causes muscle weakness and wasting ( muscular... Doses are too high cholesterol in patients taking performance-enhancing compounds, Nevill, M. Y.,,... During resistance training in healthy individuals ( those with no underlying/prior illnesses ) kingsley, M. and Perciavalle, E.. ):321-325 106 ( 1 ):393-397 by low heart rate and low oxygen levels in newborns creatine containing during. 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